Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells
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منابع مشابه
Differential regulation of NFAT 5 by NKCC 2 isoforms in medullary thick ascending limb 3 ( mTAL ) cells 4 5
26 27 The effects of Na-K-2Cl cotransporter type 2 (NKCC2) isoforms on the regulation of nuclear 28 factor of activated T cells isoform 5 (NFAT5) was determined in mouse medullary thick ascending 29 limb (mTAL) cells exposed to high NaCl concentration. Primary cultures of mTAL cells and freshly 30 isolated mTAL tubules, both derived from outer medulla (outer stripe>inner stripe), express NKCC2 ...
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The contribution of nuclear factor of activated T cells 5 (NFAT5) to the regulation of tumor necrosis factor-alpha (TNF) production in medullary thick ascending limb (mTAL) cells is unclear. RT-PCR analysis was performed on primary cultures of mouse mTAL cells and freshly isolated mTAL tubules to determine which NFAT isoforms are present in this nephron segment. Primer pairs were designed, base...
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Absorption of NH(4)(+) by the medullary thick ascending limb (MTAL) is a key event in the renal handling of NH(4)(+), leading to accumulation of NH(4)(+)/NH(3) in the renal medulla, which favors NH(4)(+) secretion in medullary collecting ducts and excretion in urine. The Na(+)-K(+)(NH(4)(+))-2Cl(-) cotransporter (BSC1/NKCC2) ensures approximately 50-65% of MTAL active luminal NH(4)(+) uptake un...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2011
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00408.2010